/ Stars that died in 2023

Saturday, November 30, 2013

J. Blackfoot, American soul singer, died from cancer he was 65.

J. Blackfoot ,[1] was an American soul singer, who was a member of The Soul Children in the late 1960s and 1970s, and subsequently had a moderately successful solo career died from cancer he was 65.. His biggest hit was "Taxi", which reached the charts in both the US and UK in 1984.

(born John Colbert, November 20, 1946 – November 30, 2011)

Biography

John Colbert was born in Greenville, Mississippi, moving to Memphis, Tennessee with his family as a child. Generally known as "J." or "Jay", he acquired the nickname "Blackfoot" as a child, for his habit of walking barefoot on the tarred sidewalks. In 1965, while spending some time in Tennessee State Penitentiary in Nashville for car theft, he met Johnny Bragg, the founder of the Prisonaires vocal group.[2] After leaving prison he recorded a single under his own name for the small Sur-Speed label, before returning to Memphis, where he was heard singing in a street corner group by David Porter of Stax Records. After the plane crash that claimed the lives of Otis Redding and four members of The Bar-Kays, he joined the reconstituted group as lead singer, and performed with them for several months but did not record.[3]
In 1968, after Sam & Dave had moved from Stax to Atlantic Records, Porter and his songwriting and production partner Isaac Hayes decided to put together a new vocal group of two men and two women. They recruited Blackfoot, together with Norman West, Anita Louis, and Shelbra Bennett, to form The Soul Children. Between 1968 and 1978, The Soul Children had 15 hits on the R&B chart, including three that crossed over to the Billboard Hot 100, and recorded seven albums.[3][4]
The Soul Children disbanded in 1979. Blackfoot worked with bands in the Memphis area, and recorded solo for the local Prime Cut label. In 1983, he began working again with writer and producer Homer Banks, with whom he had recorded with The Soul Children, and recorded "Taxi", a song originally written for Johnnie Taylor but not recorded by him. Blackfoot's record rose to no. 4 on the R&B chart and no. 90 on the pop chart, also reaching no. 48 in the UK.[5][6] He recorded several albums, and had several more R&B hits on Banks' Sound Town label before moving to the Edge label formed by Al Bell in 1986. In 1987, he had another significant hit, "Tear Jerker", a duet with Ann Hines, reaching no. 28 on the R&B chart.[4][5][7] He later moved to the Basix label, continuing to release albums into the new millennium.
In 2007, Blackfoot and West reformed the Soul Children, with Hines and fourth member Cassandra Graham.[4] In 2010, Blackfoot appeared as part of David Porter's music revue.[2]
On November 30, 2011, Blackfoot died after having been diagnosed with cancer.[2]

Discography

Albums

  • City Slicker (Sound Town, 1983)
  • Physical Attraction (Sound Town, 1984)
  • U-Turn (Edge, 1987)
  • Loveaholic (Basix, 1991)
  • Room Service (Basix, 1993)
  • Reality (Basix, 1995)
  • This Christmas (Basix, 1997)


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Patrice O'Neal, American actor and comedian (Web Junk 20, The Opie and Anthony Show), died from complications from a stroke he was 41.

Patrice Malcolm Oneal , usually credited as Patrice O'Neal, was an American stand-up comedian, radio personality, and actor died from complications from a stroke he was 41.

(December 7, 1969 – November 29, 2011)

Early life

Patrice Malcolm Oneal was born in New York City, New York,[6] on December 7, 1969, and grew up in the Roxbury neighborhood of Boston, Massachusetts.[7] His mother, Georgia, named him after Patrice Lumumba, the leader of the Congolese independence movement, and Malcolm X. He was raised by his mother and never met his father.[8]
Oneal was a star football player at West Roxbury High School, ending his career with 3 letters in varsity football and a state championship his senior year. He turned down football scholarships in order to attend Northeastern University on a public housing grant, majoring in Performing Arts.[9]
At the age of 17, Oneal was convicted of statutory rape of a 15 year old girl and sentenced to 60 days in prison[10], served during his summer break, so as not to disrupt his schooling.[11] The act, which occurred when Oneal was still 16, would have been legal in most states, but Massachusetts lacks a close-in-age exception, and has an age of consent of 16.[12] Oneal said his humor helped him to negotiate the harsh realities of prison.[11][13]

Career

Oneal began his comedy career in Boston at an open mic at Estelle's Bar and Grill in October 1992.[14] In the late 1990s, he moved to New York City, where he became a regular at the Comedy Cellar, before relocating to Los Angeles, in the hopes of finding greater fame. "I tap danced like you wouldn't believe... trying to get something," he said in a 2008 interview with Ron Bennington . "I'm telling you, if I'd have had a gun back then, I would have shot myself." His inability to achieve success on other people's terms motivated him to prioritize his own integrity first. "At the end of the day I just want to know that I was true to myself."[15] Later in his career, Patrice would walk away from successful shows like The Office, Arrested Development, Web Junk 20, and a writing position on the WWE. "I'm a professional bridge-burner," Oneal stated in an interview.[16]
Unwilling to yield to the demands of American club owners that he change his often confrontational act, Oneal relocated to the United Kingdom to work on his comedy there. He worked harder as an outsider and a foreigner to gain the respect of his peers. "It took about 5 months... for them to go 'Ok, this guy's not playing around,'" he told Bennington. It was also during this time that he caught the eye of British comedian Ricky Gervais, still early in his stand-up career.[15] Gervais frequently mentioned Oneal as a favorite comic.[17][18][19] He returned to the New York area in 2002 when he got the offer to do his first half-hour special for Showtime. Later that year he joined the cast of The Colin Quinn Show and then Tough Crowd with Colin Quinn. The following year, he recorded a Comedy Central Presents special.
Oneal's first television appearance was on The Apollo Comedy Hour where he performed his Malcolm XXL bit. From there, he moved on to appearances on Showtime at the Apollo, FNight Videos, and a brief stint as a writer for the WWE. He appeared in guest-starring roles on MTV’s Apt 2F, Assy McGee, Ed, Z Rock, Yes Dear, Arrested Development, Chappelle's Show and The Office. Oneal was a regular on the Fox series The Jury, and he starred in the Comedy Central animated program Shorties Watching Shorties, along with Nick DiPaolo. He supplied the voice of Harold Jenkins on Noggin’s animated program O'Grady High and was featured as Jesus in Denis Leary’s Searchlight. In 2005, Oneal filmed a half-hour One Night Stand special for HBO, and shortly thereafter became the first host of VH1's Web Junk 20. Oneal left the show after two seasons, expressing concerns that the show's audience was too different from his own. In 2006 and 2007 he joined Opie and Anthony's Traveling Virus Comedy Tour, playing large outdoor concert arenas across the country.

Oneal at the 2007 O&A Traveling Virus at PNC
After moving back to New York in 2002, Oneal became a recognized radio personality as a regular guest and occasional co-host on the Opie and Anthony program. Along with Bill Burr and Robert Kelly, he filled in as co-host for comedian Jim Norton while Jim filmed Lucky Louie. From 2006 to 2008, Oneal hosted a call-in relationship advice show on XM Radio, which ended when the satellite network merged with rival Sirius. Initially promoted as Bitch Management, the show was titled The Black Philip Show, a reference to Dr. Phil. Dante Nero co-hosted, and a rotating cast of female comedians played third mic. The show aired until the station suspended much of its Saturday night programming when they were unable to reconcile budget concerns with the new management following the merger. Oneal had also appeared as a guest on other radio shows such as Alex Jones along with numerous political talk shows on the Fox News channel.
Living in the New York area, Oneal performed at comedy clubs in the area, including headlining appearances at Comix Comedy Club and Caroline's. He was also popular in Montreal, making five appearances at the Just for Laughs festival, including one of the most memorable in fest history: a one-man, one-week show at Théâtre Ste. Catherine in 2008. Oneal had also been slated to do five sold-out, one-man shows at Les Katacombes at the 2010 Just for Laughs Festival, but he was refused entry into Canada at the U.S. border and the shows were cancelled.[20]
In February 2011, Comedy Central aired his first hour-long special, Elephant in the Room. He eventually began a web series and podcast called The Patrice Oneal Show - Coming Soon![21] showing various episodes as of May 15, 2007. He performed with a five-person group—Bryan Kennedy, Dante Nero, Vondecarlo Brown, Harris Stanton and Wil Sylvince—touching on many fictional scenarios. The show was produced by For Your Imagination and can be found on Oneal's website. He guest-starred in another For Your Imagination-produced show, called Break a Leg, playing Adult-Sized Gary Coleman. Oneal voiced Jeffron James in Grand Theft Auto IV, on an in-game radio show, Fizz!.
On September 19, 2011, Oneal was one of the many roasters at the Comedy Central Roast of Charlie Sheen. This would be his final television appearance before his death two months later. A little more than halfway through the show in a small interview, leading up to the commercial break, Oneal says "this should be my last show ever." Oneal's final recorded interview was with Jay Mohr on his "Mohr Stories" Podcast #17, uploaded October 27, 2011, shortly after news of his stroke.
Shortly after O'Neal's death, BSeen Media announced the release of his first album, Mr. P, to be released February 7, 2012. It was recorded at the D.C. Improv.[22] Although announced after his death, the album had been completed before his illness, with the comedian's full involvement.[23] On Nov 6, 2012, Better Than You, a 20 minute "digital single" of previously unreleased material was released on O'Neal's website and via iTunes.[24]

Illness and death

On October 19, 2011, Oneal reported being unable to move his legs, the first signs of a stroke. He was rushed to Jersey City Medical Center, and later Englewood Hospital where doctors performed surgery to remove a blood clot. He lost his ability to speak, and later his ability to move, for a time communicating by eye movements, before losing that ability as well. Doctors warned that if he survived, he would likely remain permanently paralyzed and unable to speak.[8]
Initially the family made efforts to keep news of Oneal's illness quiet. On October 26, 2011, it was announced to the public on The Opie and Anthony Show that Oneal had suffered a stroke a week earlier.[25][26] At 7:00 AM on November 29, 2011, he died from complications from his stroke.[27] Oneal was diagnosed with Type 2 diabetes while in his early twenties, and also struggled with weight issues for years.[28][29] He is survived by his longtime partner (whom he often referred to as his wife) Vondecarlo Brown, mother Georgia, stepdaughter Aymilyon, and sister Zinder.[7]
Oneal's funeral was held on December 5 at Park Avenue Christian Church in New York City, and was attended by notable comedians including Chris Rock, Colin Quinn, Nick DiPaolo, Artie Lange, Jim Norton, Dane Cook, Wanda Sykes, and Kevin Hart.[8]

Reactions and tributes

On November 30, 2011, a dozen comedians gathered to eulogize Oneal on The Opie and Anthony Show, a radio program that Oneal had appeared on over 100 times. These comedians were: Jim Norton, Bob Kelly, Louis CK, Joe Rogan, Bill Burr, Colin Quinn, Amy Schumer, Dave Attell, Jim Florentine, Russ Meneve, Joe DeRosa, and Kurt Metzger.[30] The channel dedicated its programming that weekend to the comedian, by airing a 16-hour special entitled A Tribute to Patrice O'Neal featuring some of his best appearances, along with memories from some of his fellow comedians.[31]
Always known as a comedian's comedian, Oneal was one of the best loved acts by his peers. Many comics reacted via Twitter.[32] "The best comedian in the world has died," proclaimed Norm Macdonald. Dave Attell tweeted "Patrice O. was and is one of the best comics I have ever had the pleasure to watch perform." Ricky Gervais, a long time vocal fan of Oneal's, said "One of my favourite stand up comedians. So sad. RIP." Denis Leary called him "one of the funniest men who ever walked this earth" and Bill Burr concurred, saying he was "the most purely funny human being I’ve ever met." Doug Stanhope remembered Oneal as "one of the best ever. Inspiring every time I heard him on anything." Dozens of other comedians echoed similar sentiments on Twitter.[33][34] Comedian Jon Stewart paid his respects through his "Moment of Zen" bit, in his show The Daily Show with Jon Stewart, stating: "Sad News. Once again in comedy we lose somebody, who's too funny, too soon." This statement was followed by a clip of Oneal's stand up special Elephant in the Room.[35]
Many entertainers outside of the comedy community reacted as well. Director Kevin Smith said, "I shared some air & some air time with the man on O&A & he was always funny & thoughtful. He WILL be missed." Rapper Talib Kweli said "Super funny and I had the pleasure of meeting the man. We will miss you." The Roots drummer Questlove mourned "so grateful I got to see Patrice Oneal do his last NYC gig. Man, this is so devastating. He truly was one of my favorite comics." Nick Cannon called him "An amazing comedian and an even better person."[33] Actor Charlie Sheen paid his respects through his blog, saying: "The entertainment world as well as the world at large lost a brilliant man today. Patrice had that rare "light" around him and inside of him. I only knew him for the few days leading up the Roast. Yet I will forever be inspired by his nobility, his grace and his epic talent. My tears today are for the tremendous loss to his true friends and loving family."[36]
Comedians Nick DiPaolo and Artie Lange paid tribute to Oneal on their radio show by recounting stories of the late comedian, "As a standup comic, guys like Nick and Patrice are like Babe Ruth, and on a good day I'm maybe Robin Yount," said Lange.
Comedy Central aired Oneal's special Elephant in the Room on November 30 in the wake of his death.[37]
Comedian Louis C.K. dedicated his comedy special Live at the Beacon Theater to Oneal's memory. He later commented on Twitter that O'Neal had been his favorite living comedian.[38]
Rolling Stone ran a four-page article about Oneal's career and passing in the February 16, 2012 issue.[8]
In June 2012, Jim Norton dedicated his 1 hour EPIX comedy special Please Be Offended to Oneal.
On September 23, 2012, during the 64th Primetime Emmy Awards, Oneal was remembered during the "In Memoriam" tribute.[39]
On November 26, 2012, at Gotham Comedy Club in NYC, a benefit show for Oneal's family was held. The comedians who performed sets were: Colin Quinn, Artie Lange, Wil Sylvince, Danny Lobell, and Keith Robinson.[40]
On November 29, 2012, Bill Burr announced, via Twitter, that there would be a memorial benefit show for Oneal's family on February 19, 2013. The comics who performed at New York City Center were: Colin Quinn, Jim Norton, Dave Attell, Bill Burr, Bob Kelly, Rich Vos, Keith Robinson, Ian Edwards, Wil Sylvince, and Marina Franklin.[41]

Comic style

Oneal's comedy has been described as conversational.[42] Except during televised appearances, he seldom performed standing up, preferring a relaxed, philosophical delivery.[43]
Oneal was also known as a provocateur, often inciting audience members to call out, or even leave the club. "I've seen him give people money to leave," recalls Gregg "Opie" Hughes.[44] At times he would encourage people to call out to the stage in order to set up a punchline. "Ladies, how would you keep your man if you lost your vagina?," Oneal would ask of his audience. When the women would invariably reference oral and anal sex, the comedian would respond, "See, I gave you the chance to talk and you qualified yourself as a series of holes."[42]

Discography

  • Mr. P (2012)[45]
  • Better Than You (2012) [download][46]

Filmography

Television

Year(s) Title Role Notes
2002 The Colin Quinn Show Various
2002 Contest Searchlight Himself
2002 Chappelle's Show Pit Bull 2 Episodes
2002-2004 Tough Crowd With Colin Quinn Himself/Various
2003 Yes, Dear Tow Truck Driver 1 Episode
2003 Ed Andre Stangel Uncredited
2003 Arrested Development T-Bone 1 Episode
2004 The Jury Adam Walker Recurring
2004 Shorties Watchin' Shorties Baby Patrice Voice
2004-2006 O'Grady Harold Voice
2005-2007 The Office Lonny 3 Episodes
2006 The Best Man Himself unaired Comedy Central pilot
2006 Web Junk 20 Host 2 Seasons
2008 Assy McGee Blind Anthony Voice
2008 Z Rock Stage Manager Guest Star
2011 The Roast of Charlie Sheen Himself

Film

Year(s) Title Role Notes
2002 25th Hour Khari
2003 Head of State Warren
2003 In the Cut Hector
2006 Scary Movie 4 Rasheed Uncredited
2010 Furry Vengeance Gus
2011 Elephant in the Room Himself
2012 Nature Calls Mr. Caldwell


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Guillermo O'Donnell, Argentine political scientist, died from cancer he was 75.

Guillermo O'Donnell was a prominent Argentine political scientist, named the Helen Kellogg Professor of Government and International Studies at the University of Notre Dame in the United States  died from cancer he was 75.. His brother, Pacho O'Donnell, is a well-known politician and writer.

(24 February 1936 – 29 November 2011)[1]

Biography

O'Donnell was born in Buenos Aires. He studied law at the University of Buenos Aires and became a lawyer in 1958, aged 22. He went on to earn his master's degree (1971) and Ph.D in political science (1981) from Yale University. He later served as president of the International Political Science Association from 1988 to 1991. O'Donnell became a member of the American Academy of Arts and Sciences in 1995. He was a member of the scientific committee of Fundación IDEAS, Spain's Socialist Party's think-tank.

Academic Work

Most important among his theoretical contributions to political science is his work on the 'bureaucratic-authoritarian state' and on theories of democracy and the characteristics of the process of democratic transition, through the development of concepts such as "horizontal accountability", "micro democracy" and "delegative democracy".[citation needed][clarification needed]

Death

He died in his native Buenos Aires at the age of 75 on 29 November 2011 after a four month battle with cancer.[citation needed]

Selected Publications

  • Democracy, Agency and the State: Theory with Comparative Intent (2010)
  • The Quality of Democracy: Theory and Applications (2004)
  • Desarrollo Humano y Ciudadanía: Reflexiones sobre la Calidad de la Democracia en América Latina (2003)
  • Counterpoints: Selected Essays on Authoritarianism and Democratization (1999)
  • The (Un)Rule of Law and the Underprivileged in Latin America (1999)
  • A Democracia no Brasil (1988)
  • Bureaucratic Authoritarianism: Argentina 1966-1973 in Comparative Perspective (1986)
  • Transitions from Authoritarian Rule (1986)
  • Poverty and Inequality in Latin America (1988)
  • Development and the Art of Trespassing (1986)
  • Issues in Democratic Consolidation (1982)

Awards


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Ladislas de Hoyos, French journalist and news anchor, died he was 72.

'Ladislas de Hoyos (Ladislaus Alfons Konstantin Heinrich Johannes de Hoyos) son of the Earl de Hoyos of Austria  died he was 72.

 (March 27, 1939 – December 8, 2011)

Ladislas  was a French TV journalist and politician. He was news broadcaster for TF1's and is known to have been the first journalist to interview in 1972 the former Gestapo member Klaus Barbie who was detained in Bolivia. Barbie lived under the alias of Klaus Altmann and De Hoyos managed with Beate Klarsfeld to discover where the war criminal was hidden. De Hoyos covered in 1987 the trial of Barbie in Lyon[1] and wrote a book about him.
He was elected as mayor of Seignosse in 2001 and was reelected in 2008.[2] de Hoyos died in office as mayor of Seignosse.
In 1991, Ladislas de Hoyos left the 20 hours of TF1. In 1997, he worked at Radio France Inter to produce the history magazine The Days of the Century. In 2001 he was elected mayor of Seignosse, Les Landes, position he held until his death. In July 2006, he was appointed Chevalier of the Légion d'honneur.
In 1975, he married Corinne Meilhan-Bordes, air hostess at Air France with whom he has two daughters, Amelie and Charlotte. He divorced after meeting in 1995 Magali Fernández-Salazar, young foreign journalist at Radio France Internationale, with whom he began a relationship that lasted until the end of his life.
He died December 8, 2011 in Seignosse where he is buried.


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Lloyd J. Old, 78, American immunologist and cancer researcher, died from prostate cancer he was 80.


Lloyd John Old was internationally recognized as one of the founders and standard-bearers of the field of cancer immunology died from prostate cancer he was 80..[1] When Old began his career in 1958, tumor immunology was in its infancy. Today, cancer immunotherapies are emerging as a significant advance in cancer therapy (reference?). Many of the seminal findings in the field that have led to this evolution have been contributed by Old, his students, and his colleagues.

(September 23, 1933 – November 28, 2011)

Old’s contributions to research over the past five decades established many of the principles and priorities of modern tumor immunology. In earlier work, he and his colleagues introduced Bacillus Calmette-Guérin (BCG) to tumor immunotherapy; discovered the first link between the major histocompatibility complex (MHC) and disease (leukemia); found the unexpected association between Epstein-Barr virus (EBV) and nasopharyngeal carcinoma; discovered tumor necrosis factor (TNF); defined the concept of cell-surface differentiation antigens with the discovery of TL, Lyt (CD8), and a range of other mouse antigenic systems; discovered p53, independently with two other groups; and identified the tumor immunogenicity of heat shock proteins. Old is the author or co-author of more than 700 research publications.
Prior to his death, Old held the William E. Snee Chair of Cancer Immunology at Memorial Sloan-Kettering Cancer Center (MSKCC), where he was director of the Ludwig Institute for Cancer Research (LICR) New York Branch. He was also a trustee of the LICR Charitable Trust, and a trustee of the Virginia & D.K. Ludwig Fund for Cancer Research, which created the Ludwig Cancer network in 2006. From 1971 to 2011, he served as the founding scientific and medical director of the Cancer Research Institute (CRI), where from 2001 to 2011 he also served as director of the CRI/LICR Cancer Vaccine Collaborative (CVC), an international network dedicated to testing and optimizing therapeutic cancer vaccines. Old’s previous appointments included Chairman of the LICR Board of Directors (2006–2009), LICR Scientific Director (1988 to 2005), Member of the Emeritus LICR Scientific Committee (1971–86), LICR Chief Executive Officer (1995–2004), and Associate Director of Research at MSKCC (1973–83).
As part of a distinguished service career Old served as a member of scientific advisory boards and committees including the Public Health Research Institute of the City of New York, the National Cancer Institute, and the American Association for Cancer Research. Old is also a member of the American Association for Cancer Research, New York Academy of Sciences, Reticuloendothelial Society, Society of Experimental Biology and Medicine, American Association for the Advancement of Science, American Association of Immunologists, National Academy of Sciences, the Academy of Cancer Immunology, and the American Academy of Arts and Sciences. He has also received honorary doctor of medicine degrees from Karolinska Institute, the University of Lausanne, and the University College London. He graduated from the University of California, Berkeley with a B.A. in biology and earned a medical degree from the University of California School of Medicine, San Francisco.
He died November 28, 2011, in his New York City home, after several years battling advanced prostate cancer.[1]

Contents

Major Discoveries

His findings and achievements include:
  • Introduced Bacille Calmette-Guérin (BCG), the tuberculosis vaccine, into experimental cancer research as a way to stimulate non-specific resistance to tumor growth. BCG was FDA-approved in 1991 and is now widely used as a first line treatment for superficial bladder cancer (1959).[2]
  • Discovered the first linkage between the major histocompatibility complex (MHC) and disease—mouse leukemia—opening the way for the recognition of the importance of the MHC in the immune response (1964).[3]
  • Identified the first cell surface antigens distinguishing cells of different lineages, introducing the concept of cell surface antigens that could differentiate different cell types. First coined TL (for “thymus-leukemia” antigen in mice) then later as the Ly series (originally named Ly-A and Ly-B and later called Ly-1, Ly-2, and Ly-3), this discovery led directly to the wide use of cell surface markers to distinguish and classify normal and malignant cells and the development of CD classification (for “clusters of differentiation”). Most notably, Dr. Old discovered the LY-B antigen, later renamed CD8 in humans. CD8 cells, often referred to as “killer” T cells, are one of the major cells of the adaptive immune response, and are capable of directly killing dangerous or foreign cells (1964-1968).[4][5][6][7][8]
  • Discovery of the association between Epstein-Barr Virus (EBV) and nasopharyngeal cancer (1966).[9]
  • Discovery of tumor necrosis factor (TNF), a key immune signaling molecule (cytokine) that, in addition to its promise for the treatment of cancer and other diseases, has provided a powerful research tool in biomedicine (nearly 88,000 articles in PubMed as of May 25, 2011) (1975).[10][11]
  • Identification (independently, along with two other groups) of the p53 protein, the gene for which is mutated in approximately 50 percent of cancers (1979).[12]
  • Conducting of the most comprehensive dissection of the cell surface of human cancers using monoclonal antibodies, with the identification of an array of cell surface antigens as targets for antibody-based therapies of human cancer. Of the monoclonal antibodies developed in Dr. Old’s laboratory, thirteen have been licensed and seven are in clinical trials. These include:
    • MORAb-003 (farletuzumab), currently in a phase III trial for ovarian cancer sponsored by Morphotek, which licensed the antibody from LICR. MORAb-003 targets the folate receptor alpha, which is overexpressed on a number of epithelial cancers, including ovarian, breast, renal, lung, colorectal and brain cancers.
    • the anti-EGFr antibody Hu806, which Abbott acquired exclusive world-wide rights to develop in a major licensing deal in 2008. Hu806 targets the overexpressed form of the epidermal growth factor receptor (EGFr) present in 50 percent of all cancers of epithelial origin.[13]
    • cG250 (girentuximab, Rencarex®/Redectane®), which targets the CA-IX molecule/G250 antigen, expressed on over 90 percent of clear cells renal cell carcinomas (RCC, kidney cancer), and is in phase III clinical trials as a diagnostic tool and as a therapeutic modality (also iodine-131-G250).
    • hu3S193, which targets the LeY antigen, an oligosaccharide epitope expressed on glycolipids and glycoproteins by a wide range of epithelial cancers, is in phase II clinical trials being conducted by LICR spin-off company Recepta Biopharma.
    • huA33, which targets the A33 antigen present on colorectal cancer cells. The antibody has been licensed to LICR spin-off company Life Sciences Pharmaceuticals, and the mAb’s therapeutic potential is being tested as a stand-alone antibody, as a radioimmunotherapy agent, and in combination with chemotherapy.[14]
  • Establishment of the autologous typing system as the methodology leading to the identification of the first specific human tumor antigens recognized by antibodies and T cells, created 150 separate cancer cell lines, and laid the groundwork for the development of SEREX by Pfreundschuh in 1995.[15]
  • Discovery and naming of several members of the CT (cancer/testis) family of human tumor antigens, including New York-ESO-1 (NY-ESO-1). NY-ESO-1 is one of the most immunogenic human tumor antigens discovered to date and is expressed in approximately 35 percent of melanomas, 30 percent of breast cancers, 30 percent of liver cancers, 25 percent of lung cancers, less than five percent of colon cancers.
  • Contribution to the resurrection of the cancer immunosurveillance hypothesis and to the development of the expanded model of cancer immunoediting.[16][17][18]
  • Establishment in 2001 of the Cancer Vaccine Collaborative (CVC), the world's first network of clinical trial sites closely linked with immunological monitoring laboratories with the goal to develop effective therapeutic cancer vaccines by first understanding the fundamental immunological implications of vaccination and applying that knowledge toward the rational design of optimal vaccine formulations. A joint program of the Cancer Research Institute and the Ludwig Institute for Cancer Research, the CVC conducts parallel, early phase, single variable clinical trials of various cancer vaccine formulations and combinations composed of cancer-specific antigen, immunological adjuvant, vaccine delivery platforms, and modulators of immune suppression.

Leadership

Dr. Old’s contributions to science extend far beyond his own research interests. As Director of the international Ludwig Institute for Cancer Research for 17 years, Scientific Director of the Cancer Research Institute for 40 years, and his previous appointment as Associate Director of Research at Memorial Sloan-Kettering Cancer Center for 10 years, Dr. Old has guided the scientific vision of several institutions and the training and development of generations of young scientists in many fields.

Lloyd J. Old, M.D., c. 1974
Memorial Sloan-Kettering Cancer Center (MSKCC)
  • Memorial Hospital for Cancer and Allied Diseases
    • 1973-1976: Vice President and Associate Director
    • 1976-1986: Vice President and Associate Director for Scientific Development
  • Memorial Sloan-Kettering Cancer Center
    • 1973-1983: Associate Director of Research
  • Ludwig Institute for Cancer Research, New York Branch at MSKCC
    • Director, 1990-present
Ludwig Institute for Cancer Research (LICR)
  • 1988-2005: Director
  • 1989-present: Member, Board of Directors
  • 1995-2004: Chief Executive Officer
  • 2006-2008: Chairman, Board of Directors
Virginia and D. K. Ludwig Trust

Lloyd J. Old, M.D., with Cancer Research Institute founder Helen Coley Nauts, Cancer Research Institute (CRI)
  • 1968-1971: Scientific Advisor
  • 1971-2011: Scientific Director
CRI/LICR Cancer Vaccine Collaborative (CVC)
  • 2001-2011: Director

Awards

  • 1955: Phi Beta Kappa
  • 1955: Sigma Xi
  • 1957: Roche Award
  • 1958: Alpha Omega Alpha
  • 1962: Alfred P. Sloan, Jr. Prize in Cancer Research
  • 1970: Lucy Wortham James Award, James Ewing Society
  • 1972: Lecturer, Harvey Society
  • 1972: Louis Gross Award
  • 1974: Member, Institute of Medicine, U.S. National Academy of Sciences
  • 1975: Cancer Research Institute William B. Coley Award for Discoveries in Basic and Tumor Immunology (honored as one of the "Founders of Tumor Immunology")
  • 1976: Member, American Academy of Arts and Sciences
  • 1976: Rabbi Shai Shacknai Memorial Prize in Immunology and Cancer Research
  • 1978: Member, National Academy of Sciences
  • 1978: Research Recognition Award, Noble Foundation
  • 1980: G.H.A. Clowes Memorial Lecturer
  • 1981: Robert Roesler de Villiers Award, Leukemia Society of America
  • 1985: New York Academy of Medicine Medal for Distinguished Contributions in Biomedical Science
  • 1986: Honorary Member, Japanese Cancer Association
  • 1990: Robert Koch Prize, Robert Koch Society
  • 1994: Honorary Doctor of Medicine, Karolinska Institute
  • 1995: Honorary Doctor of Medicine, University of Lausanne
  • 1997: Honorary Doctor of Sciences (Medicine), University College London
  • 2004: President's Medal, Johns Hopkins University
  • 2004: Dean's Award, Stanford University School of Medicine
  • 2004: Honorary Professor, Peking University
  • 2007: Charles Rodolphe Brupbacher Prize for Cancer Research
  • 2011: C. Chester Stock Award Lectureship, Memorial Sloan-Kettering Cancer Center


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Thursday, November 28, 2013

Ante Marković, Croatian politician, Prime Minister of the Socialist Federal Republic of Yugoslavia (1989–1991), died he was 87.

Ante Marković  was the last prime minister of the Socialist Federal Republic of Yugoslavia  died he was 87..

(pronounced [ǎːnte mǎːrkɔʋitɕ]; 25 November 1924 – 28 November 2011)[1][2]

Early life

Marković, who was a Bosnian Croat, was born in Konjic, then a part of the Kingdom of Yugoslavia, presently in Bosnia and Herzegovina. He graduated from the Electrotechnical Department of the Technical Faculty of the University of Zagreb in 1954.[3]

Political career

President of Croatia

In 1986 he became president of the Presidency of Socialist Republic of Croatia (thus becoming 7th Croatian president) replacing Ema Derosi-Bjelajac. He held that position until 1988, when he was replaced by Ivo Latin.

Prime Minister of Yugoslavia

He became prime minister in March 1989 following the resignation of Branko Mikulić. After that decision had become public, the U.S. had anticipated cooperation because Marković was known "to favor market-oriented reforms" [4] - the BBC declared that he is "Washington's best ally in Yugoslavia".[5] At the end of the year, Marković launched a new and ambitious program of unprecedented economic reforms, including stabilization of currency and privatization, as well as a program of limited trade liberalization. The result of his monetary reform was a temporary halt to inflation leading to a short-lived rise in Yugoslavia's otherwise plummeting standard of living. Nonetheless, the short-term effect of economic reforms undertaken by Marković led to a decline in Yugoslavia's industrial sector. Numerous bankruptcies occurred as the state-owned enterprises struggled to compete in a more free market environment, a fact later wielded against Marković by his many ethnic nationalist political opponents. By 1990, the annual rate of growth in GDP had declined to -7.5%. In 1991, GDP declined by a further 15 percent and industrial output decreased by 21 percent.
Marković owed his popularity to his image of a new, modern Western-styled politician. As such, he quickly became the darling of liberal circles who wanted Yugoslavia to be transformed into a modern, democratic federation. Marković also maintained popularity by staying out of increasingly virulent quarrels within the leadership of Communist League of Yugoslavia or trying to act as mediator between various republics.
When LCY broke up in January 1990, Marković had only his popularity and the apparent success of his programme on his side. In July 1990, he formed the Union of Reform Forces (Savez reformskih snaga), a political party supporting a reformed Yugoslavian federation.
This decision was not well received. Borisav Jović, then the President of Yugoslavia, commented
The general conclusion is that Ante Markovic is no longer acceptable or reliable to us. No one has any doubts in their mind any longer that he's the extended arm of the United States in terms of overthrowing anyone who ever thinks of socialism, and it is through our votes that we appointed him Prime Minister in the Assembly. He is playing the most dangerous game of treason.[6]
Jović's conclusion on Marković's role
He was no doubt the most active creator of the destruction of our economy, and to a large extent a significant participant in the break-up of Yugoslavia. Others, when boasted of having broken up Yugoslavia wanted to take this infamous role upon themselves but in all these respects they never came close to what Marković did, who had declared himself as the protagonist of Yugoslavia's survival[6]
Later, his programme was sabotaged by Slobodan Milošević who
had virtually sealed Markovic's failure by December 1990 by secretly securing an illegal loan woth $1.7 billion from Serbia's main bank in order to ease his reelection that month. The loan undermined Markovic's economic austerity program, undoing the progress that had been made toward controlling the country's inflation rate.[7]
Or, as Christopher Bennet tells it in Yugoslavia's Bloody Collapse:[8]
Quite simply, the bank printed whatever money Milošević felt he needed to get himself reelected and the size of the 'loan' became clear a few weeks later when inflation took off again throughout the country. As the economy resumed its downward slide, Marković knew his enterprise had failed [...]
The authority of the federal government was further diminished by secessionist moves in Slovenia and Croatia. In the last months of his tenure Marković tried to find compromise between secessionists and those demanding that Yugoslavia remain a single entity. His efforts, although favoured by new democratic governments in Bosnia and Macedonia, ultimately failed, because the army - which was supposed to be his greatest ally - sided with Milošević and Serb nationalists. Frustrated and politically impotent, Marković told his cabinet in September 1991 what he had gleaned from a wiretap that had come into his possession:[9]
The line has been clearly established [between the Serbian government, the army and Serb politicians in Bosnia]. I know because I heard Milošević give the order to Karadžić to get in contact with General Uzelac and to order, following the decisions of the meeting of the military hierarchy, that arms should be distributed and that the TO of Krajina and Bosnia be armed and utilised in the realisation of the RAM plan.[10]
Marković remained in office even after the start of the war, only to resign in December 1991, isolated and without any authority.

Life after 1991

After that, Marković disappeared from the public eye. In 1993 he was rumoured to be Tuđman's choice for Croatian prime minister, apparently due to his economic expertise. The post ultimately fell to Nikica Valentić, who used some of Marković's recipes to halt inflation.[11]
Marković instead dedicated himself to a business career. In the early 2000s he worked as an economic advisor to the Macedonian government.
He appeared as a witness at the Slobodan Milošević trial at the ICTY in 2003. This appearance broke his 12 years of silence; after that testimony, he gave an interview to the Zagreb-based Globus news magazine. In his testimony he stated that both Milošević and Tuđman confirmed to him that in March 1991 in Karađorđevo they made an agreement to divide Bosnia and Herzegovina between themselves.[12]
Marković died in the early hours of 28 November 2011, after a short illness.


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Lucio Magri, Italian journalist and politician, died from assisted suicide he was 79.

Lucio Magri was an Italian journalist and politician  died from assisted suicide he was 79..[1]

(19 August 1932 – 28 November 2011) 

Biography

Magri was born in Ferrara and was one of the founders of the far-left newspaper il manifesto.
He was co-founder (in 1974) and secretary of the Proletarian Unity Party for Communism (or PdUP), which later merged with the Italian Communist Party in 1984. When the latter renounced communism to become the Democratic Party of the Left in 1991, Magri adhered to the Communist Refoundation Party, founding an internal movement whose structure recalled that of PdUP.
In 1995 his movement split, to form the Movement of Unitarian Communists, born to support a centre cabinet led by Lamberto Dini. When the Movement entered the newly formed Democratic Party of the Left, Magri abandoned it, devoting himself only to il manifesto.
In 2009 he published an essay on the history of the Italian Communist Party, entitled Il sarto di Ulm. Una possibile storia del PCI (The Ulm tailor. A possible history of the P.C.I.). In 2011, Verso Books published 'The Tailor of Ulm: Communism in the Twentieth Century'. Reviewing the book in Review 31, John Green praised it as 'an invaluable platform for understanding the apparent impasse of the present global and systemic crisis'.
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Dickey Betts died he was 80

Early Career Forrest Richard Betts was also known as Dickey Betts Betts collaborated with  Duane Allman , introducing melodic twin guitar ha...